Table 1 Genes Dys-regulated in TG Mice vs WT Controls Five Days After DOX-treatment.

From: Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein

Upregulated (Fold Increase)

Downregulated (Fold Increase)

Apoptosis

Btg2 (2.67)

Lcn2 (2.27)

Phlda3 (2.52)

Hmox1 (2.04)

Dnase2a (2.11)

Plscr1 (1.72)

Asns (2.09)

Mical1 (1.72)

Mmp2 (2.08)

Nr4a1 (1.67)

Cxcl12 (2.05)

Zfp110 (1.61)

Sh3kbp1 (1.99)

Malt1 (1.56)

Igf1 (1.85)

Bcl2l1 (1.54)

Slit2 (1.78)

Mknk2 (1.54)

Chac1 (1.75)

Ntn1 (1.54)

Pla2g4a (1.73)

Casp9 (1.52)

Aen (1.72)

Dapk1 (1.52)

Bcl2 (1.62)

Xrcc5 (1.52)

Sfrp1 (1.62)

Bik (1.52)

Ccng1 (1.60)

 

Grk5 (1.59)

 

Ptgfr (1.58)

 

Fhl2 (1.57)

 

Atf5 (1.57)

 

Pf4 (1.56)

 

Cycs (1.55)

 

Extracellular matrix and/or genes associated with fibrosis

Postn (3.17)

Cyr61 (3.57)

Col3a1 (2.76)

Ctgf (1.96)

Olfml2b (2.62)

Spock2 (1.52)

Lgals3 (2.55)

 

Sulf2 (1.79)

 

Col1a2 (1.73)

 

Smoc2 (1.69)

 

Col5a2 (1.67)

 

Egflam (1.64)

 

Col1a2 (1.64)

 

Col1a1 (1.53)

 

Crispld2 (1.50)

 

Col5a1 (1.50)

 

Ndufs4 (1.50)

 

Cell growth/proliferation

Cxcl12 (2.05)

Tacc2 (1.72)

Nppa (1.87)

Bcl2l1 (1.54)

Slit2 (1.78)

Xrcc5 (1.52)

Pla2g4a (1.73)

 

Myocd (1.63)

 

Sfrp1 (1.62)

 

Bcl2 (1.62)

 

Fanca (1.62)

 

Atf5 (1.57)

 

Emp1 (1.53)

 

Serpine2 (1.52)

 

Nf2 (1.52)

 

Cgrrf1 (1.50)

 

Heart development/embryonic skeletal system development/actin cytoskeleton organization/multicellular organismal development

Wif1 (2.47)

Sorbs1 (1.82)

Dnase2a (2.11)

Enah (1.67)

Eda2r (2.04)

Dmd (1.61)

Pdlim7 (1.89)

Vamp5 (1.59)

Sulf2 (1.79)

Flnb (1.56)

Slit2 (1.78)

 

Sema3c (1.74)

 

Myocd (1.63)

 

Sfrp1 (1.62)

 

Bves (1.61)

 

Ptpla (1.60)

 

Cap1 (1.54)

 

Sema3b (1.54)

 

Col1a1 (1.53)

 

Nf2 (1.52)

 

Serpine2 (1.52)

 

Hypertrophy

Igf1 (1.85)

Lmcd1 (1.67)

Immune/inflammatory response

Clec4n (2.14)

Plscr1 (1.89)

Cxcl12 (2.05)

Cblb (1.61)

Ccl8 (1.93)

 

Slit2 (1.78)

 

Ccl12 (1.71)

 

Ly96 (1.67)

 

C3ar1 (1.58)

 

Ccl6 (1.57)

 

Pf4 (1.56)

 

Ccl9 (1.5)

 

Oxidation-reduction process

Cyp2b10 (4.00)

Cp (2.17)

Mthfd2 (3.13)

Fmo2 (1.92)

Pam (1.90)

Fdft1 (1.82)

Aldh1l2 (1.74)

Mical1 (1.72)

Asph (1.73)

D2hgdh (1.67)

Loxl2 (1.69)

Cyp2d22 (1.64)

Loxl1 (1.67)

P4htm (1.64)

Aldh18a1 (1.60)

Dmd (1.61)

Mecr (1.59)

Gpd1 (1.61)

Nqo2 (1.54)

Vamp5 (1.59)

Hsd17b7 (1.52)

Hsd17b10 (1.59)

Ndufs4 (1.50)

Bckdhb (1.56)

 

Glrx3 (1.56)

 

Cat (1.54)

 

Fmo5 (1.52)

 

Tet2 (1.52)

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