Figure 2
Intravascular filament occlusion of the middle cerebral artery (MCA) may lead to displacement of its origin.
Depicted are examples in which a short tubing-based silicone coated (S-TB) filament tip, a commercially available filament (DOC) and a bowling pin-shaped (BP) filament tip were used. The origin of the right-sided MCA is indicated by a white arrow head (right side) and a black arrow head (left side). The proximal and distal ball-shaped thickenings of the BP filament are indicated by curved arrows. Note the split origin of the MCA in the case shown on the right. Such a deviation may occur in up to 10% of a given batch of rats. The overlay indicates how the degree of displacement (indicated by the length of the black arrow) was measured. This displacement shows a good correlation (top right panel) with ischemic damage (as calculated from AUC in this case) produced in the occipital part of the brain in S-TB and DOC-tip filament groups (n = 5 in each group). Scale bar = 1 mm. AUC, area under curve. Linear regression was conducted by least squares method.
