Table 1 Laser Doppler flow reduction (upon occlusion of the middle cerebral artery origin), ischemic volume, hemispheric swelling and mortality in different filament groups at 24 h of permanent middle cerebral artery occlusion.

From: Long-term survival in permanent middle cerebral artery occlusion: a model of malignant stroke in rats

 

Type of occluding filament

L-TB (n = 6)

S-TB (n = 6)

DOC (n = 6)

BP (n = 7)

LDF reduction (%)#

58.7 ± 8.9

60.9 ± 11.3

71.0 ± 5.7

67.7 ± 9.8

Ischemic volume (mm3)#

448.3 ± 78.3*

423.2 ± 50.6*

551.8 ± 113.8*

306.4 ± 30.0

Hemispheric swelling (%)#

35.9 ± 5.7

36.5 ± 7.9

37.1 ± 9.9

28.9 ± 7.4

Mortality (died/total no.)$

7/13

11/17

0/6@

1/8**

Total number of animals

• underwent permanent MCAO: 46

• not allowed to recover from anesthesia due to LDF traces indicative of subarachnoid hemorrhage during filament insertion: 2, excluded from all analyses

• allowed to recover from anesthesia but died before 24 h: 19, excluded from infarct analyses

• survived the 24 h period: 25, included in infarct analyses

  1. LDF, laser Doppler flow; L-TB, long tubing-based silicone coated filament tip; S-TB, short tubing-based silicone coated filament tip; DOC, commercially purchased filament (Doccol Corp., Sharon, MA, USA); BP, bowling pin-shaped filament tip. #Data represent animals which survived the 24 h observation period. *p < 0.05 vs. BP tip. The values of ischemic brain damage are corrected for swelling to improve comparison between the groups. Values are represented as mean ± SD. Statistical significance was determined by a one-way ANOVA with Tukey’s test. $A significant association was observed between the groups and mortality [χ2(3) = 11.44, n = 44, p = 0.01] using Chi-Square test with Bonferroni correction. @Between group comparison in DOC group is precluded by absence of deaths. **p < 0.05 vs S-TB using between group comparison with Bonferroni correction. MCAO, middle cerebral artery occlusion.
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