Table 2 Time-related changes of ischemic damage in bowling pin-shaped tip occluded rats undergoing permanent middle cerebral artery occlusion.

From: Long-term survival in permanent middle cerebral artery occlusion: a model of malignant stroke in rats

BP group

24 h (n = 7)

72 h (n = 7)

120 h (n = 6)

Ischemic volume (mm3)

306.4 ± 30.0

434.1 ± 63.1*

355.9 ± 103.1

Hemispheric swelling (%)

28.9 ± 7.4

29.1 ± 4.8

13.2 ± 1.9**

AUC-Frontal region (%)

48.5 ± 9.4

55.5 ± 8.7

41.9 ± 9.5

AUC-Middle region (%)

64.7 ± 5.3

68.9 ± 3.6

62.7 ± 3.5

AUC-Occipital region (%)

20.1 ± 14.3

32.3 ± 15.5

22.4 ± 17.2

  1. BP, bowling pin-shaped filament tip; AUC, area under the curve.
  2. *p < 0.05 vs. 24 h, **p < 0.001 vs 24 and 72 h. Values are represented as mean ± SD. Statistical significance was determined by a one-way ANOVA with Tukey’s test.
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