Figure 4
From: The space of enzyme regulation in HeLa cells can be inferred from its intracellular metabolome
Reaction-level differences of enzymatic activity.
(A) Reactions with significantly (corrected p < 0.05) altered enzyme activities between HeLa and HaCaT cell lines are indicated by colored arrows in the direction of the alteration together with their mean fold changes. Regulations that are necessary for proliferation (worst case corrected p < 0.05) are marked with green asterisks. (B) Log-fold changes between all combinations of HeLa and HaCaT samples (3 biological replicates each). Colors from blue to red denote log-fold changes and columns are sorted by increasing p-values from left to right. The upper bounds for the fluxes absolute log-fold changes as estimated from flux variability analysis are shown in green.
