Figure 5: NMR-Structure of huPrP with bound xenon.

The NMR structure of huPrP with xenon bound was calculated from the NMR data starting with the 20^th structure of 2KUN. (a) Overlay of the structure in the presence (red) and absence of xenon (green). (b) Lowest energy structure with residues showing significant effects induced by binding of xenon and/or by applying high pressure^15,22. Residues showing only xenon effects > σ₀ (red) and in addition high pressure effects > 2σ₀ (orange). Residues showing high pressure effects > σ₀ only are depicted in blue, residues not detectable (e.g. prolines) or with smaller effects are depicted in grey.