Figure 7: Mapping of paramagnetic effects on spin labeled full-length prion protein. | Scientific Reports

Figure 7: Mapping of paramagnetic effects on spin labeled full-length prion protein.

From: Structural transitions in full-length human prion protein detected by xenon as probe and spin labeling of the N-terminal domain

Figure 7

Paramagnetic effects of MTSL and maleimide-linked nitroxyl spin label on huPrP variants G93C (a) and T107C (b), respectively. Very strong paramagnetic effects > 2 σ0 are colored in orange, strong effects > σ0 in red, small and negative effects < σ0 are colored in blue and unassigned residues in grey. The labeling position is displayed as spheres and the alanine-rich region in sticks. Mapping of the paramagnetic effects and in silico mutagenesis was done with Pymol (Schrödinger LLC) and the first structure of PDB entry 2KUN.

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