Figure 1: PIAS4 up-regulation and SIRT1 down-regulation accompany steatosis-associated liver fibrosis in mice. | Scientific Reports

Figure 1: PIAS4 up-regulation and SIRT1 down-regulation accompany steatosis-associated liver fibrosis in mice.

From: Transcriptional repression of SIRT1 by protein inhibitor of activated STAT 4 (PIAS4) in hepatic stellate cells contributes to liver fibrosis

Figure 1

Male db/db mice were fed on the MCD diet or a control diet (chow) for 4 weeks. (A,B) Expression of SIRT1 and PIAS4 was examined by qPCR (A) and Western blotting (B). (C) Binding of PIAS proteins to the SIRT1 promoter was evaluated by ChIP.

Back to article page