Figure 1
From: A new autoinhibited kinase conformation reveals a salt-bridge switch in kinase activation
Ribbon representation of the structure of autoinhibited EphA2.
The N-terminal lobe (N-lobe) contains five β strands (1 through 5; colored pink), the JMS and a conserved αC-helix. The C-lobe is mostly helical (colored cyan). The loops are colored grey while the activation segment is colored orange. The “Mg2+-binding loop” in the activation segment is highlighted in the boxed insert. The salt-bridge interactions between Asp757 and Arg762 in the activation segment are shown as black dashed lines.
