Table 5 Estimates from a multiple linear regression model for age, adjusting for gender, ethnicity (all patients) tumor location and histology type among patients Stages I,II,III disease.

From: Time-to-Progression of NSCLC from Early to Advanced Stages: An Analysis of data from SEER Registry and a Single Institute

Age difference(years): Stages I,II,III(T1~3/Nx/M0)

All patients n = 34845

Caucasian n = 28657

African-American n = 3322

Asian n = 2866

Adjusted mean

 age(years),stage IA

68.96(68.93~68.99)

69.59(69.57~69.61)

66.19(66.08~66.30)

65.46(65.38~65.53)

 IB vs. IA

0.13(0.09~0.18), p < 0.001

0.13(0.10~0.17), p < 0.001

0.37(0.18~0.56), p < 0.001

0.43(0.31~0.55), p < 0.001

 IIA vs. IA

0.25(0.19~0.32), p < 0.001

0.25(0.22~0.30), p < 0.001

0.22(−0.01~0.45), p = 0.062

0.98(0.83~1.14), p < 0.001

 IIB vs. IA

0.39(0.33~0.46), p < 0.001

0.34(0.30~0.4), p < 0.001

0.59(0.34~0.83), p < 0.001

1.09(0.91~1.28), p < 0.001

 IIIA vs. IA

0.58(0.52~0.65), p < 0.001

0.56(0.50~0.62), p < 0.001

0.54(0.36~0.73), p < 0.001

0.95(0.83~1.08), p < 0.001

 IIIB vs. IA

0.83(0.76~0.91), p < 0.001

0.80(0.73~0.88), p < 0.001

1.00(0.74~1.26), p < 0.001

1.38(1.15~1.61), p < 0.001

Adjusted mean

 age(years),T1a

68.92(68.89~68.95)

69.56(69.54~69.57)

66.16(66.02~66.29)

65.40(65.32~65.48)

 T1b vs. T1a

0.08(0.03~0.14), p = 0.002

0.08(0.05~0.11), P < 0.001

0.04(−0.17~0.24), p = 0.727

0.49(0.35~0.62), P < 0.001

 T2a vs. T1a

0.15(0.10~0.19), P < 0.001

0.18(0.15~0.21), P < 0.001

0.39(0.21~0.58), P < 0.001

0.59(0.48~0.71), P < 0.001

 T2b vs. T1a

0.63(0.56~0.70), P < 0.001

0.52(0.48~0.57), P < 0.001

1.25(0.99~1.52), P < 0.001

1.42(1.23~1.6), P < 0.001

 T3 vs. T1a

0.62(0.57~0.69), P < 0.001

0.35(0.31~0.38), P < 0.001

0.76(0.54~0.97), P < 0.001

1.23(1.08~1.38), P < 0.001

 T4 vs. T1a

0.92(0.85~0.99), P < 0.001

0.84(0.77~0.91), P < 0.001

0.92(0.67~1.17), P < 0.001

1.21(1.02~1.41), P < 0.001

Adjusted mean

 age(years),N0

69.09(69.07~69.11)

69.70(69.69~69.71)

66.45(66.36~66.53)

65.76(65.7~65.82)

 N1 vs. N0

0.09(0.03~0.15), p = 0.002

0.12(0.08~0.16), p < 0.001

−0.03(−0.2~0.25), p = 0.826

0.73(0.58~0.89), p < 0.001

 N2 vs. N0

0.12(0.08~0.17), p < 0.001

0.16(0.12~0.19), p < 0.001

0.25(0.08~0.43), p = 0.004

0.69(0.57~0.82), p < 0.001

 N3 vs. N0

0.56(0.45~0.66), p < 0.001

0.43(0.1~0.24), p < 0.001

0.77(0.43~1.1), p < 0.001

0.93(0.6~1.25), p < 0.001

  1. Values given are mean differences in ages by tumor size and stage of disease, with 95%CIs.
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