Table 6 Estimates from a multiple linear regression model for age, adjusting for gender, race (all patients) tumor location, histology type among patients Stages I, II, III disease.

From: Time-to-Progression of NSCLC from Early to Advanced Stages: An Analysis of data from SEER Registry and a Single Institute

Age difference (years):Stages I,II,III (Tx/Nx/M0)

Adenocarcinoma n = 12381

Squamous cell carcinoma n = 22464

Adjusted mean

 age(years),stage IA

68.25 (68.21~68.29)

71.46(71.42~71.50)

 IB vs. IA

0.91(0.53~1.28), p < 0.001

0.24(−0.22~0.71), p = 0.307

 IIA vs. IA

−0.06(−0.56~0.44), p = 0.813

0.75(0.21~1.15), p = 0.008

 IIB vs. IA

−0.16(−0.68~0.35), p = 0.524

1.82(1.26~2.46), p < 0.001

 IIIA vs. IA

0.38(−0.76~0.1), p = 0.057

1.64(1.23~2.12), p < 0.001

 IIIB vs. IA

1.17(0.47~1.87), p = 0.001

2.52(1.90~3.10), p < 0.001

Adjusted mean

 age(years),T1a

67.57(67.53~67.61)

70.96(70.94~71.01)

 T1b vs. T1a

0.17(−0.28~0.63), p = 0.453

0.45(−0.19~1.10), p = 0.109

 T2a vs. T1a

1.04(0.68~1.39), p = 0.036

−0.21(−0.76~0.27), p = 0.391

 T2b vs. T1a

1.44(0.8~2.08), P < 0.001

−0.39(−1.00~0.21), p = 0.201

 T3 vs. T1a

1.66(1.26~2.05), p < 0.001

0.57(0.32~1.12), p = 0.038

 T4 vs. T1a

0.92(0.31~1.5), p = 0.003

1.82(1.21~2.46), p < 0.001

Adjusted mean

 age(years),N0

68.60(68.54~68.66)

71.43(71.39~71.46)

 N1 vs. N0

1.14(0.67~1.62), p < 0.001

1.89(1.03~2.76), p < 0.001

 N2 vs. N0

1.08(0.69~1.48), p < 0.001

1.92(1.54~2.46), p < 0.001

 N3 vs. N0

1.62(0.7~2.56), p = 0.001

3.01(2.49~3.53), p < 0.001

  1. Values given are mean differences in ages by tumor size and stage of disease, with 95%CIs.
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