Figure 1: Chemical structure of plumbagin (a) and the inhibitory effects of CYPs activities by plumbagin in pooled human liver microsomes (b) and pooled rat liver microsomes (c).

Chemical structure was produced using ChemDraw Professional 15.0. Results were mean ± SD of quadruplicate assays. The data was fit to log (plumbagin concentration) and normalized response equations using GraphPad Prism 5.0.