Figure 5: Sigmoidal auto-activation kinetics curve of CYP3A2 by various concentrations of plumbagin (0 
, 1
, 2
, 5 
, 10 ♦ μM) in rat liver microsomes.
, 1
, 2
, 5 
, 10 ♦ μM) in rat liver microsomes.
Midazolam was used at concentrations of 2.5, 5, 10, 20, 40 and 80 μM. Insets show the corresponding Eadie-Hofstee plots for CYP3A2 kinetic profile.
