Table 3 Neuromuscular junction (NMJ) phenotypes of R-spondin (Rspo2), agrin (Agrn), wnt4 (Wnt4) and β-catenin (Ctnnb1) deficient mice.
From: R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5
Knocked out gene | Rspo2 | Agrn 54 | Wnt4 15 | Ctnnb1 18 |
|---|---|---|---|---|
AChR clusters | ||||
Size | ↑ | ↓ | ↑ | ↑ |
Band width of AChR clusters | ↑ | ↑ | ↑ | ↑ |
Basal lamina | Normal | Patchy | n.a. | Normal |
Synapses | ||||
Synaptic cleft | Widened | Widened | n.a. | Normal |
Postsynaptic fold | ↓ | ↓ | n.a. | n.a. |
Motor axons | ||||
Terminal arborization | Increased branches | Increased branches | Increased branches | Decreased branches |
Nerve terminals | ||||
Number of active zones | ↓ | ↓ | n.a. | ↓ |
Number of synaptic vesicles | ↓ | ↓ | n.a. | ↓ |
