Figure 3: CTNNB1 polymorphisms affected CTNNB1 mRNA level and its transcriptional activity. | Scientific Reports

Figure 3: CTNNB1 polymorphisms affected CTNNB1 mRNA level and its transcriptional activity.

From: Pathway Analyses Identify Novel Variants in the WNT Signaling Pathway Associated with Tuberculosis in Chinese Population

Figure 3

Notes: ALL: all subjects, TB: tuberculosis patients, HC: healthy controls. W H: wild homozygote, M H: mutant homozygote. (A,B) refer to the CTNNB1 mRNA levels in relation to different genotypes in all 79 subjects [GC + GG vs CC: 3.15 (0.64–33.68) vs 27.28 (4.37–103.38)], 50 TB patients [30.24 (6.93–62.69) vs 47.08 (21.59–131.98)] and 29 healthy controls [0.64 (0.53–2.85) vs 0.83 (0.50–2.31)], respectively. rs3864004, rs9859392 and rs9870255 were in strong linkage disequilibrium, and their genotypes had the same CTNNB1 mRNA expression level, therefore, we just listed rs9859392 as an example. Subjects were grouped for rs9859392 in CTNNB1 as genotype with (GG + GC) or without (CC) mutant G allele. (C) indicates the effect of three CTNNB1 polymorphisms on CTNNB1 promoter transcriptional activity in 293T cells. Each bar represents the mean of triplicate transfected plates plus standard deviation (rs3864004: 0.83 ± 0.04 vs 0.09 ± 0.01; rs9859392: 0.40 ± 0.05 vs 0.25 ± 0.02; rs9870255: 0.48 ± 0.01 vs 0.30 ± 0.08).

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