Table 3 Association of WNT pathway polymorphisms with TB risk in Chinese Han population.

From: Pathway Analyses Identify Novel Variants in the WNT Signaling Pathway Associated with Tuberculosis in Chinese Population

Gene

SNP

Additive Model

Dominant Model

Recessive Model

OR

P*

P**

OR

P*

P**

OR

P*

P**

CTNNB1

rs9859392C > G

0.76 (0.65–0.88)

4.00 × 10−4

0.010

0.69 (0.57–0.84)

1.35 × 10−4

0.003

0.82 (0.54–1.24)

0.344

 
 

rs9870255G > C

0.77 (0.65–0.90)

8.00 × 10−4

0.019

0.73 (0.61–0.88)

0.001

0.026

0.68 (0.45–1.05)

0.079

 
 

rs3864004G > A

0.78 (0.67–0.91)

0.002

0.039

0.75 (0.62–0.90)

0.003

0.063

0.68 (0.45–1.03)

0.071

 

WIF1

rs34203757C > G

0.92 (0.78–1.09)

0.340

 

0.92 (0.76–1.13)

0.434

 

0.81 (0.50–1.31)

0.391

 
 

rs34505206C > G

0.88 (0.74–1.04)

0.130

 

0.86 (0.71–1.05)

0.146

 

0.81 (0.50–1.30)

0.374

 
 

rs56900803G > T

1.00 (0.82–1.22)

0.990

 

0.96 (0.77–1.20)

0.731

 

1.64 (0.76–3.52)

0.205

 

DKK1

rs11001553C > T

1.04 (0.82–1.33)

0.740

 

1.04 (0.80–1.35)

0.787

 

1.20 (0.43–3.31)

0.732

 
 

rs1896367G > A

0.98 (0.86–1.13)

0.790

 

1.04 (0.87–1.25)

0.655

 

0.81 (0.60–1.11)

0.186

 
 

rs1896368G > A

0.96 (0.84–1.09)

0.500

 

1.04 (0.86–1.25)

0.722

 

0.80 (0.62–1.03)

0.079

 

SFRP1

rs3242C > T

0.97 (0.75–1.24)

0.790

 

0.87 (0.65–1.16)

0.347

 

2.47 (0.98–6.22)

0.055

 
 

rs4736958T > C

0.78 (0.70–0.92)

0.002

0.040

0.73 (0.61–0.88)

7.41 × 10−4

0.017

0.82 (0.61–1.10)

0.183

 
 

rs72643819G > T

1.11 (0.98–1.26)

0.100

 

1.06 (0.88–1.28)

0.544

 

1.34 (1.05–1.70)

0.019

0.447

 

rs7832767C > T

1.29 (1.10–1.46)

0.001

0.023

1.26 (1.03–1.49)

0.022

0.505

1.81 (1.30–2.52)

4.29 × 10−4

0.010

WNT1

rs4760662C > T

1.01 (0.89–1.14)

0.920

 

0.97 (0.78–1.19)

0.747

 

1.05 (0.85–1.30)

0.631

 
 

rs4760663C > T

1.01 (0.89–1.14)

0.920

 

0.92 (0.75–1.13)

0.433

 

1.11 (0.90–1.38)

0.323

 

WNT3A

rs13373831A > G

0.94 (0.80–1.10)

0.410

 

0.86 (0.71–1.04)

0.119

 

1.35 (0.87–2.08)

0.179

 
 

rs708113T > A

1.04 (0.91–1.18)

0.610

 

0.98 (0.81–1.18)

0.801

 

1.21 (0.93–1.58)

0.165

 
 

rs74672629C > G

0.92 (0.74–1.14)

0.430

 

0.90 (0.71–1.13)

0.352

 

1.28 (0.45–3.67)

0.644

 
 

rs752107C>T

0.85 (0.73–0.99)

0.040

0.928

0.82 (0.68–0.98)

0.033

0.766

0.86 (0.58–1.26)

0.433

 

WNT5A

rs2076831C > G

1.03 (0.91–1.18)

0.610

 

1.07 (0.89–1.29)

0.461

 

1.00 (0.76–1.30)

0.93

 
 

rs3732750G > A

1.23 (1.00–1.52)

0.053

 

1.23 (0.98–1.55)

0.068

 

1.71 (0.63–4.60)

0.292

 
 

rs504849A > G

1.00 (0.87–1.14)

0.970

 

1.00 (0.83–1.20)

0.968

 

1.00 (0.77–1.30)

0.988

 
 

rs566926A > C

1.01 (0.89–1.16)

0.850

 

1.10 (0.91–1.32)

0.344

 

0.89 (0.68–1.15)

0.357

 
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