Figure 3
From: Paternal overweight is associated with increased breast cancer risk in daughters in a mouse model
Effect of paternal overweight on female offspring’s mammary gland differentiation.
(a) Histological depiction of the 4th inguinal mouse mammary gland on PND 50 showing terminal end buds (TEB, indicated by arrows) and (b) number of TEBs (n = 5–6/group) on PND50 in control and OID female offspring. (c) Histological depiction of the 4th inguinal mouse mammary gland on PND 50 showing ductal elongation (indicated by arrow, cm) and (d) body weight-adjusted ductal elongation (cm, n = 5–6/group)) on PND50 in control and OID female offspring. All values are expressed as the mean ± s.e.m. Significant differences versus the control group assessed by t-test. P < 0.05 is considered significant; exact P values are shown in each plot. LN, lymph node; scale bars: 0.5 mm (a) and 3 mm (c). Mammary tissues analyzed represent litters from 3–4 different fathers/group.
