Table 2 Serum cytokine levels in control subjects and CP/CPPS patients, and their correlation with NIH-CPSI, SAS, and SDS.

From: The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders

Cytokines

Concentration (pg/ml)

Correlation coefficient (r)

Controls

CP/CPPS

NIH-CPSI

SAS

SDS

IL-1α

4.292 ± 0.435

8.617 ± 1.105 *

0.144

0.020

−0.094

IL-1β

4.685 ± 0.727

7.840 ± 1.244 *

0.232

0.438**

0.373**

IL-4

0.900 ± 0.119

3.287 ± 0.879 *

0.020

0.005

−0.013

IL-6

4.867 ± 0.302

5.907 ± 0.733

0.009

−0.142**

−0.176**

IL-8

6.680 ± 0.79

8.015 ± 0.857

−2.586

−1.958

−2.366 **

IL-10

0.866 ± 0.035

0.970 ± 0.057

−0.016 **

−0.003

−0.005

IL-13

0.253 ± 0.017

0.579 ± 0.074 *

−0.005

−0.002

−0.002

MCP-1

175.1 ± 5.873

191.5 ± 6.848

−1.449

0.514

−0.128

TNF-α

5.422 ± 0.486

8.151 ± 0.947 *

0.425 **

0.349 **

0.290 **

IFN-γ

2.091 ± 0.192

2.401 ± 0.282

0.007

−0.023

−0.057

  1. IL: interleukin; MCP: monocyte chemokine protein; TNF: tumor necrosis factor; IFN: interferon; Mean values ± SD are reported for all parameters.
  2. *CP/CPPS compared to controls when p < 0.05 (Student’s t-test).
  3. **The index correlated to cytokines when p < 0.05 (Spearman rank correlation).
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