Figure 1 | Scientific Reports

Figure 1

From: Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain

Figure 1

Capsazepine (CPZ) enemas attenuate murine DSS colitis independently of TRPV1.

(A) Representative colonoscopy photographs during the course of DSS (5%) colitis at days 2, 4 and 6 (d2, d4, d6) (each group n = 8). Comparison of WT and TRPV1-deficient mice without CPZ (531 μM) enemas with WT and TRPV1−/− mice that were treated twice daily with CPZ enemas from day 0. (B) Endoscopic score (Mann Whitney U-test) (C) course of body weight analysis of variance (ANOVA) followed by Fisher’s LSD test, (D) histological examination (HE staining) and (E) histological score (Mann Whitney U-test) in the different groups. All *P < 0.05, **P < 0.01.

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