Figure 8 | Scientific Reports

Figure 8

From: XBP1 splicing triggers miR-150 transfer from smooth muscle cells to endothelial cells via extracellular vesicles

Figure 8

A schematic illustration of PDGF-IRE1α-XBP1-miR-150 pathway in EC-SMC interaction.

Under ischemia, the activated ECs may secret PDGF, which in turn activates IRE1α phosphorylation, leading to XBP1 mRNA splicing to remove 26-nucleotide intron in SMCs. The spliced XBP1 stabilizes miR-150 and increases its secretion via extracellular vesicles (EVs). The miR-150-containing EVs are taken by ECs, increasing VEGF-A mRNA transcription or stability, leading to VEGF-A protein production and secretion. VEGF-A triggers the ErK and Akt phosphorylation via binding to VEGF receptor in an autocrine or paracrine manner. The activated Akt contributes to EC migration, leading to angiogenesis.

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