Figure 4: Gene expression profiles in corpus callosum extracts from BCAS and BCAS + EA groups. | Scientific Reports

Figure 4: Gene expression profiles in corpus callosum extracts from BCAS and BCAS + EA groups.

From: Electroacupuncture ameliorates memory impairments by enhancing oligodendrocyte regeneration in a mouse model of prolonged cerebral hypoperfusion

Figure 4

Gene expression profiles were evaluated using the Mouse Growth Factors RT2 profiler PCR array. (A) Scatter plot summarizing gene expression analyses. The middle diagonal gray line indicates 1-fold change (no change of gene expression between both groups). Circles above this gray line indicate an increase gene expression, and circles below indicate a decrease in expression, BCAS + EA versus BCAS group. The two outer gray lines indicate a 2-fold change. The 11 red circles represent genes that showed a >2-fold incrsease in expression in the BCAS + EA versus BCAS group comparison. 3 genes (Figf, Mdk, and NT4/5) are indicated by arrows. (B) The table shows select genes (Figf, Mdk, and NT4/5), that demonstrated differential expression between the BCAS and BCAS + EA groups. Numbers in bold indicate upregulated genes. (C–E) Fold change in expression of the 3 selected genes as detected by quantitative real-time PCR analysis. Figf, c-fos induced growth factor; Mdk, midkine; NT4/5, neurotrophin-4/5. Data expressed as the mean (±SEM). *P < 0.05 vs. BCAS group.

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