Figure 7: EA stimulation promotes CREB activation in the corpus callosum following prolonged cerebral hypoperfusion. | Scientific Reports

Figure 7: EA stimulation promotes CREB activation in the corpus callosum following prolonged cerebral hypoperfusion.

From: Electroacupuncture ameliorates memory impairments by enhancing oligodendrocyte regeneration in a mouse model of prolonged cerebral hypoperfusion

Figure 7

(A,B) Double immunofluorescent staining of pCREB and NG2 or CNPase in the sham control condition and histogram analysis of pCREB-positive cells also identified as OPCs and OLs. Arrowheads indicate double-labeled cells. Scale bar = 25 μm. (C,D) Numbers of pCREB-positive (pCREB+) cells at days 14 and 28 post-BCAS induction and pCREB histogram analysis. Scale bar = 100 μm. (E) pCREB Western blot images. The histogram indicates the mean (±SEM) of 3 independent experiments. Data expressed as the mean (±SEM). *P < 0.05, and ***P < 0.001 vs. sham control; #P < 0.05, or ###P < 0.001 vs. BCAS group.

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