Figure 5
From: Network Modeling Identifies Patient-specific Pathways in Glioblastoma
(A) NUMB protein as a tumor invasiveness marker. Entries with highly invasive tumors are colored red. Minimally or non-invasive tumor entries are colored blue. Entries with tumors containing Numb in the modeled network are colored red. (B) Known NUMB activity leads to ubiquitination of MDM2 and in turn increases p53 level. NUMB activity also inhibits Notch signaling. The first degree neighbors of NUMB in the interactome have other ubiquitin ligases including SIAH1, LNX1 and ITCH.
