Table 4 Permeation parameters of CUR formulations through the excised corneas (mean ± S.D., n = 3).

From: Potential advantages of a novel chitosan-N-acetylcysteine surface modified nanostructured lipid carrier on the performance of ophthalmic delivery of curcumin

 

Eye drops

NLC

CH-NLC

CS-NACL-NLC

CS-NACM-NLC

CS-NACH-NLC

Jss (0–60 min) (×10−4 μg·cm−2·s−1)

3.20 ± 0.35

10.13 ± 0.21 a

15.3 ± 0.33 a , b

46.06 ± 0.15 a , b , c

57.65 ± 0.61 a , b , c , d

65.56 ± 0.64 a , b , c , d , e

Jss (60–360 min) (×10−4 μg·cm−2·s−1)

1.66 ± 0.07

3.30 ± 0.06 a

5.12 ± 0.03 a , b

14.98 ± 0.07 a , b , c

20.05 ± 0.06 a , b , c , d

21.4 ± 0.34 a , b , c , d

Papp (0–60 min) (×10−6 cm·s−1)

0.54 ± 0.04

1.69 ± 0.09 a

2.55 ± 0.02 a , b

7.67 ± 0.11 a , b , c

8.71 ± 0.06 a , b , c , d

10.90 ± 0.21 a , b , c , d , e

Papp (60–360 min) (×10−6 cm·s−1)

0.19 ± 0.01

0.56 ± 0.02 a

0.85 ± 0.02 a , b

2.99 ± 0.12 a , b , c

3.35 ± 0.10 a , b , c , d

3.57 ± 0.05 a , b , c , d

R2(0–60 min)

0.9954 ± 0.0017

0.9994 ± 0.0005

0.9998 ± 0.0004

0.9986 ± 0.0012

1.0000 ± 0.0003

0.9998 ± 0.0002

R2(60–360 min)

0.9981 ± 0.0023

0.9997 ± 0.0008

0.9953 ± 0.0001

1.0000 ± 0.0002

0.9999 ± 0.0013

0.9999 ± 0.0011

  1. aStatistically significant compared with the eye drops (p < 0.05).
  2. bStatistically significant compared with the NLC (p < 0.05).
  3. cStatistically significant compared with the CH-NLC (p < 0.05).
  4. dStatistically significant compared with the CS-NACL-NLC (p < 0.05).
  5. eStatistically significant compared with the CS-NACM-NLC (p < 0.05).
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