Figure 1: Scheme of Bc2 RNA secondary structure and multiple sequence alignments of Bc2 RNAs.

(a) Schematic representation of full length and terminated cap transcripts. TSSs (+1) are labeled by bent arrows. AUG is the start code. (b) Sequence alignments of Bc2 RNAs from B. thuringiensis and B. cereus with Vc2 RNA. White letters shaded in magenta, orange, green and black denote the conserved nucleotides of A, G, and C and U, respectively. The predicted c-di-GMP binding sites were highlighted by red stars, with the consensus sequences of Bc2 RNAs depicted below the alignments. The aptamer region and expression platform were underlined by blue and brown lines, respectively.