Table 2 Time Points Key Pathways (hr versus control).

From: Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules

Time point	Selected Processes	Result	Ref (e.g.)
6 v C	Decrease in cytokine signaling	Certain cytokines block adipogenesis	19,20,67
6 v C	Differential transcription factor regulation (e.g., JUN, FOS)	Cell cycle arrest, promotion of adipogenesis	76, 77, 78, 79
48 v C	Transamination	Decreased amino acid catabolism	68
	PPAR Signalling Pathway	Nuclear receptor signaling	80
	7 pathways associated with ribosome function	New protein synthesis	21
	Differential regulation of actin and related proteins	Changes in cytoskeletal structures	81, 82, 83
	Insulin	Insulin responsiveness	84
	Integrin	Cell surface remodelling	85
	Branched chain amino acid	Branched chain amino acid	68,86, 87, 88
	Synthesis of very long chain FA	Fat Metabolism	89
	Oxidative phosphorylation	Mitochondrial function	90
	Leptin	Leptin signalling
96 v C	PPAR-γ pathway	PPAR signalling	74,91
	Focal adhesion/integrin	Cell remodelling	92
	Insulin signalling	Insulin responsiveness	84
	Pathogenic response to E. Coli	Tubulin and associated processes	82
	Leptin	Leptin signalling	67
	Pathways associated with ribosome function	New protein synthesis	21
192 v C	WNT signalling	Coupling signalling to transcription	93,94
	Insulin signalling	Insulin responsiveness	84
	Metabolism of proteins	Protein & mitochondrial synthesis	21
	PPAR, VDR_RXR	Nuclear receptor signalling	74,80,91
	Peroxisome	Fatty acid metabolism
	IL5, ERK, ILK, P53	Cell signaling
	Prolactin receptor signalling	Regulation of glucose/lipid & transporters	95
	Porphyrin metabolism	Linked to WNT signaling	96
	Pyruvate, Citrate and TCA cycle	Changes in energy metabolism	97
	Branched chain amino acid	Lipid & energy production	68,86,87
384 v C	Insulin pathway	Insulin responsiveness	84
	Glucose metabolism	Energy metabolism & precursors	67
	Adipokine networks	Cell signalling	98
	Integrin	Extracellular matrix	85
	Leptin	Adipokine signaling	67,98
	Cell cycle	Maintenance of cell state	99
	Branched chain amino acid	Lipid & energy production	68

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Table 2 Time Points Key Pathways (hr versus control).

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