Table 4 Time Lapse Key Pathways.
Time lapse | Selected Processes | Result | Ref (e.g.) |
|---|---|---|---|
6 v 0 | Decrease in cytokine signaling | Certain cytokines block adipogenesis | |
Differential transcription factor regulation | Cell cycle arrest, promotion of adipogenesis | ||
48 v 6 | IL signalling pathways | Signalling through JAK/STAT | |
Peroxisome & UnsatFA synthesis | Fatty acid metabolism | ||
Prolactin receptor signalling | Regulation of glucose/lipid & transporters | ||
Pathogenic E. coli | Changes in cytoskeletal structures | ||
PPAR-γ pathway | Nuclear receptor signalling | ||
NOTCH2,3,4 | Signalling | ||
TGF-β | Signalling | ||
Integrin | Extracellular matricx | ||
96 v 48 | PPAR-γ pathway | PPAR signalling | |
Focal adhesion/integrin | Cell remodelling | ||
Insulin signalling | Insulin responsiveness | ||
Leptin & adipokine | Adipokine signaling | ||
Unsaturated fatty acid synthesis | Fatty acid metabolism | ||
Glyoxlate, dicarboxylate, glycine, serine, threonine | Precursors including for fatty acid biosynthesis | ||
NOTCH, TGFB, TRIAL, CTCF | Cell signalling | ||
Citrate and TCA cycle | Changes in energy metabolism | ||
Syndecan | Link ECM to signalling pathways | ||
P53 pathway | Cell cycle control | ||
192 v 96 | WNT signalling | Coupling signalling to transcription | |
Insulin signalling | Insulin responsiveness | ||
Glucose metabolism | Changes in energy metabolism | ||
PPAR signalling | PPAR signalling | ||
FOXM1 | Multipl with DNA repair | ||
Peroxisome, FA metabolism | Fatty acid metabolism | ||
IL5, ERK, ILK, P53 | Cell signaling | ||
Porphyrin metabolism | Linked to WNT signaling | ||
Regulation of pyruvate dehydrogenase, Citrate & TCA cycle | Changes in energy metabolism | ||
Syndecan | Link ECM to signalling pathways | ||
Branched chain amino acid | Lipid biosynthesis | ||
384 v 192 | Na independent glucose transporters | Increased glucose & fructose uptake | |
FRA Pathway | Transcriptional regulations | ||
Integrin 4 | Basement membrane structure | ||
NGF and Toll | Cell signaling | ||
IGF1 Pathway | Adipose regeneration | ||
Insulin signalling | Insulin responsiveness | ||
Cardiaegf | Calcium regulation |
