Figure 1: 3,6-DHF inhibits EMT in BC cells in vitro and in vivo. | Scientific Reports

Figure 1: 3,6-DHF inhibits EMT in BC cells in vitro and in vivo.

From: 3,6-dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway

Figure 1

(A) Western blot detections for the level of EMT markers in MDA-MB-231 and MCF-7 cells treated with different doses of 3,6-DHF (0, 5, 10, and 20 μM) for 24 h. (B) Immunofluorescence analysis for the level of snail and E-cadherin in MDA-MB-231 cells treated with different doses of 3,6-DHF for 24 h. (C) The effect of 3,6-DHF administration (20 mg/kg) on the growth of breast tumors monitored by in vivo luminescence imaging system. (D) Immunohistochemistry detections of snail, twist, slug and E-cadherin in breast tumors. The data are presented as the means ± SD (n = 3). Each data point represents the mean SEM of three independent experiments. *P < 0.05 compared with control.

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