Figure 2: 3,6-DHF inhibits BCSCs in vitro and in vivo. | Scientific Reports

Figure 2: 3,6-DHF inhibits BCSCs in vitro and in vivo.

From: 3,6-dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway

Figure 2

(A) 3,6-DHF treatment significantly decreased the percentage of ALDH-positive population in BC cells MDA-MB-231 and SUM-159. (B) Effects of 3,6-DHF treatment on cells viability in BCSCs detected by CCK-8 assay. (C) Mammosphere formation assay of non-adherent spherical clusters in BC cells treated with different dose of 3,6-DHF. (D) 3,6-DHF administration (20 mg/kg) significantly reduced the ALDH-positive populations in tumor cells in athymic mice. (E) The tumor-initiating capacity of the tumor cells derived from primary xenografts in NOD/SCID mice. The data are presented as the means ± SD (n = 3). Each data point represents the mean SEM of three independent experiments. *P < 0.05, **P < 0.01 compared with control.

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