Figure 3: 3,6-DHF inhibits migration and invasion of BC cells in vitro and in vivo. | Scientific Reports

Figure 3: 3,6-DHF inhibits migration and invasion of BC cells in vitro and in vivo.

From: 3,6-dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway

Figure 3

(A) Invasion assays in 3,6-DHF-treated BC cells using Transwell chambers. (B) The wound-healing assays in 3,6-DHF-treated BC cells. (C) The effect of 3,6-DHF on BC metastasis in vivo by a lung metastasis model. MDA-MB-231-Luc-GFP cells were injected via the lateral tail veins and optical in vivo imaging of cancer metastasis was monitored with IVIS. (D) Representative images of corresponding hematoxylin-eosin-stained lung sections at 5 weeks post-injection. The data are presented as the means ± SD (n = 3). Each data point represents the mean SEM of three independent experiments. *P < 0.05, **P < 0.01 compared with control.

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