Table 1 Enzyme and cell-based assays profile of (-)-SCR1693.
Assay | Test Concentration (M) | % Inhibition of Control Values | % of Control Values | Reference Compound | IC50 Ref (M) | nH Ref | ||
|---|---|---|---|---|---|---|---|---|
1st | 2nd | Mean | ||||||
CDK5 /p35 | 3.0E-05 | −5 | 105.2 | 104.1 | 104.6 | staurosporine | 2.1E-08 | 1.2 |
GSK3beta | 3.0E-05 | −3 | 106.4 | 98.8 | 102.6 | staurosporine | 9.9E-08 | 1.6 |
MARK1 | 3.0E-05 | −4 | 100.7 | 107.8 | 104.2 | staurosporine | 1.5E-08 | 2.9 |
MARK2 | 3.0E-05 | 7 | 93.5 | 91.5 | 92.5 | H-89 | 8.3E-06 | 2.9 |
MARK3 | 3.0E-05 | 4 | 95.8 | 96.9 | 96.3 | staurosporine | 1.7E-08 | 1.6 |
MARK4 | 3.0E-05 | 2 | 98.5 | 97.1 | 97.8 | hymenialdisine | 3.6E-08 | 1.4 |
