Figure 2: Proliferation of pancreatic β cells is inhibited in rodent models of type 2 diabetes. | Scientific Reports

Figure 2: Proliferation of pancreatic β cells is inhibited in rodent models of type 2 diabetes.

From: RIG-I inhibits pancreatic β cell proliferation through competitive binding of activated Src

Figure 2

Min6 cells were stimulated with glucolipotoxicity, TNF-α and LPS for 24 h, as indicated in Fig. 1. (A) DNA synthesis was analysed using EdU labelling assays. Representative micrographs of EdU labelling assays in MIN6 cells are shown (scale bar = 120 μm). The percentage of EdU-positive β cells was quantified. Flow cytometric assays were performed to determine the percentages of MIN6 cells at the (B) G1 phase and (C) S phase. Data are means ± SEM of three separate experiments. *P < 0.05 versus control.

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