Figure 5 | Scientific Reports

Figure 5

From: Multiple cone pathways are involved in photic regulation of retinal dopamine

Figure 5

TTX specifically blocks ipRGC input to DACs.

Experiments were conducted using wild-type TH::RFP mice. (a) A typical DAC exhibited an inward current at light onset (top black trace), which was partially blocked by L-AP4 (top grey trace). The L-AP resistant response is mediated by input from ipRGCs. Application of TTX abolished the L-AP4-resistant light response (bottom grey trace), indicating that TTX blocks ipRGC input to DACs. (b) A DAC had an inward current at light onset (top black trace), which was completely blocked by L-AP4, suggesting that this current is mediated by ON bipolar cells. After washout of L-AP4 (bottom dark trace), application of TTX increased the light-evoked inward current (bottom grey trace). Stimulation bar under each trace shows timing of a 470-nm light pulse. Light stimulus duration was 3 s.

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