Figure 6 | Scientific Reports

Figure 6

From: Multiple cone pathways are involved in photic regulation of retinal dopamine

Figure 6

ipRGCs convey cone signals from ON bipolar cells to DACs.

Experiments were performed using cone-function-only mice. (a) TTX completely blocked the ON response of a DAC, indicating that this cell received input from ON bipolar cells indirectly via ipRGCs (n = 6). (b) TTX partially inhibited the peak current amplitude of an ON response of a DAC, indicating that the cell received input from ON bipolar cells both directly and indirectly via ipRGCs (n = 9). (c) TTX increased the peak current amplitude of the ON response of a DAC, indicating this cell only receives input directly from ON bipolar cells (n = 12). Stimulation bar under each trace shows timing of a 470-nm light pulse. Light stimulus duration was 3 s. (d) Out of 32 cells tested, light-evoked ON responses were either eliminated or suppressed by TTX in 15 cells (black bar), while they were not affected in 5 cells (grey bar) and were enhanced in 12 cells (striped bar).

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