Figure 1

Characterization of glycine receptor-mediated currents recorded in rat GCs.

(A) Representative current response of a GC clamped at −60 mV, which was elicited by local puff (500 ms) of 100 μM glycine at intervals of 2 min to the dendrites in a rat retinal slice. The current was reversibly suppressed by 1 μM strychnine (Stry). The time- and amplitude-scale bars shown below the current trace are for the current responses. Durations of drug applications are indicated by horizontal lines above the current traces. (B) Bar chart summarizing the effects of 1 μM strychnine on glycine currents of GCs (n = 5). ***P < 0.001 vs. control. (C) Average current-voltage relationship of glycine-induced currents from 5 GCs. Current responses for each cell at different holding potentials were normalized to the response obtained at −100 mV. The data are presented as means ± SEM in all figures.