Figure 8
From: Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells
ATP suppresses glycine receptor-mediated L-IPSCs of OFF-GCs via P2Y receptor activation.
(A) L-IPSCs from an OFF-GC, clamped at 0 mV, were elicited by a 3-second, full-field light stimulus in the presence of bicuculline and TTX. Application of 100 μM ATP suppressed the L-IPSC reversibly. The L-IPSC was completely eliminated by 1 μM strychnine (Stry). (B) L-IPSCs from an OFF-GC, showing that, in the presence of PPADS (PP) (100 μM) and suramin (Sur) (50 μM), application of 100 μM ATP no longer suppressed the current. (C) ATP did not change the L-IPSC of an OFF-GC during internal infusion of 3 mM GDP-β-S.
