Figure 2
From: Cargo binding promotes KDEL receptor clustering at the mammalian cell surface
(A) Schematic representation of (left) the minimal model of receptor cycle between the PM and endosomes and (right) the simulation method. An example of a randomly chosen area for endocytosis (vesicle arrival) is marked in red (blue). Possible scenarios for the evolution of the surface receptor population during the next simulation step are shown. (B) Time evolution of the density of accumulated cargo at the cell surface. A comparison is made between experimental data, simulation results (a single realization) and the analytical expressions Eqs 2 and 3. The dotted line indicates the analytical prediction via Eq. 2 for αgain = αloss = 1.3 × 10−4 s−1. The starting time of simulations and analytical expression 2 is shifted to take into account the initial inactive regime in experiments.
