Figure 4
From: A novel AhR ligand, 2AI, protects the retina from environmental stress
Ligands of AhR Modulate levels of intra-cellular fatty acids in human RPEs (A) Heat map of the relative changes in intra-cellular saturated and unsaturated fatty acids in response to treatment with AhR activators (20 nM TCDD or 10 μM 2AI) and inhibitor (25 μM aNF) for 48 hr in hESC-RPE cells. (B) Relative levels of intra-cellular palmitoleic acid (PA) in response to treatment with 2AI, TCDD or aNF in hESC-RPE cells. (C) Viability of 4HNE treated human ARPE19 cells in the presence or absence of palmitoleic acid. (n = 4, *p < 0.05).
