Figure 4

(A) Correlation of nCr and connectivity-based module eigengenes of modules one and ten. (B) GSEA identifies biological functions and GO Terms (MSD v5.1 C5) and associated pathways (MSD v5.1 C2, H1). (C) nCr associated genes are clustered by Spearman’s rank correlation into three clusters. Bars below the heatmap describe the IDH1-status and the expression subgroup of each patient. (D) Volcano plot of differential gene expression analysis. Genes of the mesenchymal subgroup are marked in red, proneural genes in green. The significance level of the corrected p-values is indicated as *p < 0.05, **p < 0.01, ***p < 0.001.