Table 1 The amount of excess iron found in the whole liver and spleen at 24 h post SPION injection (5 mg Fe/kg).

From: Iron overload by Superparamagnetic Iron Oxide Nanoparticles is a High Risk Factor in Cirrhosis by a Systems Toxicology Assessment

 

Cirrhotic

Normal

Liver

Spleen

Liver

Spleen

weight (g) 1

1.636 ± 0.380 *

0.109 ± 0.014

0.842 ± 0.097

0.110 ± 0.009

excess Fe (μg) in the organ 2

100.4 ± 23.3

14.9 ± 1.9

114.8 ± 13.3

2.8 ± 0.2

% of excess Fe in SPIONs injected 3

80.3 ± 18.2

11.9 ± 1.5

91.8 ± 10.6

2.2 ± 0.2

  1. 1The weights of the liver and the spleen were the mean ± SD obtained from eight mice in the cirrhosis or control group. There was no statistical difference between the mice injected with SPIONs and the control without SPION injection.
  2. 2The excess Fe found in the organ was calculated from the weight of the organ times the difference of Fe levels between the mice injected with SPIONs and the controls from Fig. 1.
  3. 3The percent of excess Fe in SPIONs injected was obtained by the amount of excess Fe found in the organ divided by the total iron (125 μg) in the SPIONs injected.
  4. *P < 0.01 as compared with that of the normal liver.
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