Figure 5
From: Early hippocampal volume loss as a marker of eventual memory deficits caused by repeated stress
Performance on the object displacement task after the end of chronic stress.
(a) Protocol: The habituation phase was followed immediately by training phase. The testing phase was conducted 6 hours after the end of training (see materials and methods). (b) The location of the four objects in the arena along with the visual cue during the training sessions. (c) The location of the four objects in the arena along with the visual cue during the testing session. The object represented by the yellow square is the displaced object. The empty yellow square represents the location in the training session. The black arrow represents the direction of the displacement in location. (d) The change in exploration rate of each object for the unstressed (N = 10) and stressed (N = 9) group (mean ± SEM). The yellow bars represent object3 (displaced object). The unstressed group shows a significant increase in exploration rate of displaced object, i.e. object3 as compared to the other objects. The stressed group does not show any significant difference in the change of exploration for all the four objects (Factor stress: F(1, 17) = 4.160, p = 0.0572; factor objects: F(3, 51) = 5.838, p = 0.0017; interaction: F(3, 51) = 2.942, p = 0.0417). An asterisk indicates significant differences (*p < 0.05 level, Tukey’s test for multiple comparisons).
