Table 1 Volumetric measures in unstressed and stressed animals.

From: Early hippocampal volume loss as a marker of eventual memory deficits caused by repeated stress

Measure

Unstressed (N = 10)

Stressed (N = 9)

Unstressed vs stressed (difference)

Day 3 TBV (mm3)

1352.72 ± 8.36

1341.79 ± 10.36

ns

Day 7 TBV (mm3)

1354.33 ± 8.83

1348.64 ± 9.05

ns

Day 11 TBV (mm3)

1350.66 ± 8.15

1340.31 ± 10.38

ns

Day 3 THV (mm3)

97.31 ± 0.58

92.50 ± 1.06

**

Day 7 THV (mm3)

96.99 ± 0.74

90.41 ± 1.06

****

Day 11 THV (mm3)

96.51 ± 0.96

88.31 ± 0.86

****

Day 3 LHV (mm3)

47.71 ± 0.54

44.48 ± 0.80

**

Day 7 LHV (mm3)

47.84 ± 0.61

43.03 ± 0.69

****

Day 11 LHV (mm3)

47.38 ± 0.73

42.84 ± 0.43

****

Day 3 RHV (mm3)

49.60 ± 0.46

48.02 ± 0.37

ns

Day 7 RHV (mm3)

49.16 ± 0.62

47.38 ± 0.61

ns

Day 11 RHV (mm3)

49.13 ± 0.38

45.48 ± 0.80

****

  1. Stress causes a loss in total hippocampal volume (Factor stress: F(1, 17) = 58.74, p < 0.0001; factor time: F(2, 34) = 4.930,p = 0.0132; interaction: F(2, 34) = 2.274, p = 0.1183). Interestingly, the stress induced loss in hippocampal volume was asymmetrical across both the hemispheres (Factor stress (between subjects): F(1, 17) = 58.738, p < 0.001; factor time (within subject): F(2, 34) = 4.071, p = 0.026; factor hemisphere (within subject): F(1, 17) = 78.904, p < 0.001;interaction stress*hemisphere: F(1, 17) = 8.076, p = 0.011).TBV is Total Brain Volume, THV is Total Hippocampal Volume, LHV is Left Hippocampal Volume and RHV is Right Hippocampal. The day indicated is the day in the experimental paradigm mentioned in Fig. 1. (ns denotes not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).
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