Table 1 Histogram metrics of pharmacokinetic parameters of DCE-MRI and analysis on difference.

From: Dynamic Contrast-enhanced MR Imaging in Renal Cell Carcinoma: Reproducibility of Histogram Analysis on Pharmacokinetic Parameters

Kinetic Parameters

Histogram Metrics

Intra-observer

Inter-observer

Scan-rescan

1st Measurement

2nd Measurement

P value

Observer 1

Observer 2

Observer 3

P value

1st Scan

2nd Scan

P value

K trans

Mean (min−1)

0.466 ± 0.140

0.465 ± 0.145

0.878

0.466 ± 0.140

0.457 ± 0.132

0.461 ± 0.137

0.986

0.466 ± 0.140

0.450 ± 0.092

0.581

Mode (min−1)

0.370 ± 0.194

0.372 ± 0.189

0.754

0.370 ± 0.194

0.374 ± 0.196

0.402 ± 0.170

0.899

0.370 ± 0.194

0.325 ± 0.128

0.306

Skewness

0.622 ± 0.396

0.613 ± 0.374

0.638

0.622 ± 0.396

0.575 ± 0.281

0.654 ± 0.336

0.850

0.622 ± 0.396

0.653 ± 0.389

0.870

Kurtosis

−0.752 ± 0.494

−0.758 ± 0.512

0.927

−0.752 ± 0.494

−0.532 ± 0.658

−0.878 ± 0.362

0.268

−0.752 ± 0.494

−0.708 ± 0.543

0.854

K ep

Mean (min−1)

0.822 ± 0.353

0.835 ± 0.352

0.339

0.823 ± 0.353

0.833 ± 0.358

0.839 ± 0.368

0.972

0.823 ± 0.353

0.760 ± 0.347

0.160

Mode (min−1)

0.600 ± 0.300

0.550 ± 0.266

0.339

0.600 ± 0.300

0.525 ± 0.186

0.599 ± 0.300

0.732

0.600 ± 0.300

0.550 ± 0.266

438

Skewness

4.634 ± 1.398

4.671 ± 1.370

0.083

4.634 ± 1.398

4.490 ± 1.720

4.532 ± 1.215

0.971

4.634 ± 1.398

5.121 ± 1.206

0.097

Kurtosis

23.593 ± 13.392

23.954 ± 13.166

0.111

23.593 ± 13.392

23.126 ± 14.327

22.271 ± 12.777

0.971

23.593 ± 13.392

28.691 ± 12.979

0.104

Ve

Mean (min−1)

0.559 ± 0.107

0.558 ± 0.105

0.651

0.559 ± 0.107

0.551 ± 0.116

0.553 ± 0.118

0.985

0.559 ± 0.107

0.576 ± 0.107

.0423

Mode (min−1)

0.508 ± 0.231

0.511 ± 0.230

0.491

0.508 ± 0.231

0.517 ± 0.229

0.517 ± 0.216

0.995

0.508 ± 0.231

0.578 ± 0.224

0.116

Skewness

0.330 ± 0.370

0.386 ± 0.476

0.253

0.330 ± 0.370

0.290 ± 0.467

0.290 ± 0.425

0.730

0.330 ± 0.370

0.231 ± 0.572

0.322

Kurtosis

−0.692 ± 0.485

−0.577 ± 0.619

0.245

−0.692 ± 0.485

−0.712 ± 0.581

−0.623 ± 0.640

0.928

−0.692 ± 0.485

−0.722 ± 0.746

0.816

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