Figure 3: Total RNA extracted from MSC isolated from BM (n = 3), fetal (n = 3), and adult lung biopsies of lung-transplanted patients with good outcome (n = 3) was analyzed by microarray chip.
From: MSC from fetal and adult lungs possess lung-specific properties compared to bone marrow-derived MSC
We found 338 genes that were differentially expressed between bone marrow derived MSC and fetal lung MSC. When comparing bone marrow derived MSC to adult lung MSC 235 genes were found to be significantly differently expressed. Furthermore, 89 genes were found to be differently expressed when comparing lung derived MSC (both fetal and adult lung) with bone marrow derived MSC. Data are presented as a Venn diagram. Further, the 89 identified genes were divided into higher and lower expressed genes in lung MSC compared to BM-derived MSC and genes were further categorized into GO biological processes and GO pathways. The PANTHER classification system was used to further classify identified genes.
