Figure 7 | Scientific Reports

Figure 7

From: G-protein-coupled receptor kinase 2 terminates G-protein-coupled receptor function in steroid hormone 20-hydroxyecdysone signaling

Figure 7

Diagram interpreting the function and mechanism of GRK2 in the 20E signal pathway.

(1) 20E up-regulates the expression of GRK2 by EcR-B1 and USP1; (2) 20E regulates PKC phosphorylation of GRK2 at serine 680 via ErGPCR-2; (3) The phosphorylated GRK2 moves toward the cell membrane, where it interacts with and phosphorylates ErGPCR-2; (4) The phosphorylated ErGPCR-2 is internalized to the cytoplasm to terminate 20E signaling8. Pathway Builder Tool 2.0 was used to draw the figure.

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