Figure 5
Comparisons of dose-response sensitivity and robustness produced by different mechanisms.
(A) Dose-response curves produced by the 7 mechanisms. (B) Illustration of the definition of dose-response sensitivity. (C) Dose-response sensitivity for the 7 mechanisms. (D) Robustness of the 7 models to various perturbations (K164R; K172R; no unanchored ubiquitin chains [Ub], K164 and 172R; K164 only; K172 only). For each model, the average robustness with respect to 6 perturbations is also shown. See detailed results in Supplementary Table S1. (E) The product of sensitivity and robustness. Hierarchical mechanism 1 exhibited the greatest value of the product of sensitivity and robustness.
