Figure 7
Nod2-induced pathogenesis during lethal infections is independent of adaptor protein Rip2.
Nod2−/−, Rip2−/− and WT mice (n = 5 mice per group) were infected with N. caninum tachyzoites (LD100) and the body temperature (A), weight (B) and survival (C) of these mice were monitored over time. Statistical significance of the parameters was calculated using two-way analysis of variance followed by Bonferroni post-hoc test. Survival curves were compared using Kaplan–Meier survival analysis through log-rank Mantel–Cox test. In another experimental group, Nod2−/−, Rip2−/− and WT mice (n = 5 mice/group) were infected with sub-lethal doses of tachyzoites (1.107 tachyzoites) and the levels of IL-6 were measured in peritoneal exudates by ELISA, 5 days post-infection (D). Histological analysis was realized in pancreas (E) collected from the groups. *Statistical difference (*P ≤ 0.05; **P ≤ 0.01) between WT mice and the deficient mouse lineages tested.
