Figure 5 | Scientific Reports

Figure 5

From: Genome-wide analysis of HIF-2α chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions

Figure 5

Analysis of HIF-2α binding motifs.

HIF-2α binding profile of single nucleotide (a) or dinucleotide (b) composition generated by using RSAT. (c) The three most significant HIF-2α binding motifs under normoxia produced by MEME. (d) PWM Tools was used to scan the HOCOMOCO for EPAS1 motif 1 and ARI3A motif 2 against BEAS-2B and 786-O. (e) Analysis of HIF-2α potential heterodimers binding motif under normoxia. Results were generated by using dyad-analysis in RSAT. Significance index (sig) was computed by “sig = −log10(E value)” and E value = P value × number of tested character. Higher value means less error. *, de novo binding motifs that did not match those of any of known DNA binding proteins in the databank. (f) Co-enrichment of HIF-2α and SP-1 on Peak ID 151 annotated to PDXK.

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