Figure 5 | Scientific Reports

Figure 5

From: Rosette-Disrupting Effect of an Anti-Plasmodial Compound for the Potential Treatment of Plasmodium falciparum Malaria Complications

Figure 5

Rosette-disruption properties of modified heparins and other glycosaminoglycans.

Rosetting FCR3S1.2R parasites grown in (A) O+ or in (B) A+ erythrocytes were treated for 2 h with 100 μg/ml of Bovine-sourced heparin (Hep Bov) that was unmodified (NS_2S_6S), 2-O-desulfated (NS_2__6S), partially 2-O, 6-O desulfated (NS_2$_6$), N-desulfated (N__2S_6S), 2-O, 6-O desulfated (NS_2__6_), N, 2-O desulfated (N__2__6S), N desulfated and partially 2-O, 6-O desulfated (N__2$_6$), N, 2-O, 6-O desulfated (N__2__6__), Heparan sulfate, Chondroitin sulfate A (CSA), Chondroitin sulfate C (CSC), Keratan sulfate, E. coli cell wall polysaccharide K5 (K5) or PBS control. Cells were analysed by flow cytometry and the percentage of multiplets after treatment are indicated (**P < 0.01, ***P < 0.001, ****P < 0.0001 when compared to DMSO control, N ≥ 3).

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