Figure 3: The effect of SIRT1 overexpression via adenovirus injection on alcohol-induced hepatic steatosis. | Scientific Reports

Figure 3: The effect of SIRT1 overexpression via adenovirus injection on alcohol-induced hepatic steatosis.

From: Suppression of PPARγ-mediated monoacylglycerol O-acyltransferase 1 expression ameliorates alcoholic hepatic steatosis

Figure 3

(a) Schedule of SIRT1 adenovirus injection. Ad-SIRT1 or Ad-GFP was introduced via tail vein injection at 2 weeks after initiation of ethanol feeding. The mice were sacrificed 2 weeks later. (b) Western blot analysis showing SIRT1 expression in the liver of Ad-GFP- and Ad-SIRT1-injected mice. (c) H&E staining performed on liver sections from mice. (d) Body weight, liver weight, hepatic TG, and cholesterol content. (e) Real-time PCR analysis of PPARγ and MGAT1 expression. (n = 5) Data represent the mean ± SD. *P < 0.05.

Back to article page